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How RNA modifications regulate the antiviral response.

Matthew G ThompsonMatthew T SaccoStacy M Horner
Published in: Immunological reviews (2021)
Induction of the antiviral innate immune response is highly regulated at the RNA level, particularly by RNA modifications. Recent discoveries have revealed how RNA modifications play key roles in cellular surveillance of nucleic acids and in controlling gene expression in response to viral infection. These modifications have emerged as being essential for a functional antiviral response and maintaining cellular homeostasis. In this review, we will highlight these and other discoveries that describe how the antiviral response is controlled by modifications to both viral and cellular RNA, focusing on how mRNA cap modifications, N6-methyladenosine, and RNA editing all contribute to coordinating an efficient response that properly controls viral infection.
Keyphrases
  • gene expression
  • crispr cas
  • nucleic acid
  • innate immune
  • public health
  • single cell