Neuroprotection and neuroregeneration of retinal ganglion cells after intravitreal carbon monoxide release.

Julia StifterFelix UlbrichUlrich GoebelDaniel BöhringerWolf Alexander LagrèzeJulia Biermann

Published in: PloS one (2017)

Intravitreal CORM ALF-186 protected RGC after IRI and stimulated their axons to regenerate in vitro. ALF conveyed anti-apoptotic, anti-inflammatory, and growth-associated signaling after IRI. CO's role in neuroregeneration and its effect on retinal glial cells needs further investigation.

Keyphrases

induced apoptosis
anti inflammatory
cell cycle arrest
diabetic retinopathy
cell death
vascular endothelial growth factor
endoplasmic reticulum stress
age related macular degeneration
signaling pathway
neuropathic pain
pi k akt
subarachnoid hemorrhage