Saturated Heterocyclic Aminosulfonyl Fluorides: New Scaffolds for Protecting-Group-Free Synthesis of Sulfonamides.
Sergey A ZhershOleksandr P BlahunIryna V SadkovaAndrey A TolmachevYurii S MorozPavel K MykhailiukPublished in: Chemistry (Weinheim an der Bergstrasse, Germany) (2018)
Cyclic saturated aminosulfonyl fluorides were synthesized as their HCl salts. The compounds were found to be stable upon storage and could be used for the protecting-group-free synthesis of sulfonamides. In the presence of the -SO2 F group, the nitrogen atom could be modified by means of acylation, arylation, or reductive amination to give products that have high potential for the synthesis of bioactive compounds.
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