Preparation, characterization and preliminary pharmacokinetic study of pH-sensitive Hydroxyapatite/Zein nano-drug delivery system for doxorubicin hydrochloride.

Liqiong ZhaBeilei WangJiajia QianBrock FletcherCaiyun ZhangQiannian DongWeidong ChenLufeng Hong

Published in: The Journal of pharmacy and pharmacology (2020)

In this study, HA/Zein-DOX NPs represented an antitumour drug delivery system for DOX in clinical tumour therapy with improved bioavailability and decreased cardiotoxicity.

Keyphrases

drug delivery
cancer therapy
bone marrow
simultaneous determination