Investigating Halloysite Nanotubes as a Potential Platform for Oral Modified Delivery of Different BCS Class Drugs: Characterization, Optimization, and Evaluation of Drug Release Kinetics.

Tazeen Husain Muhammad Harris ShoaibFarrukh Rafiq AhmedRabia Ismail Yousuf Sadaf FarooqiFahad SiddiquiMuhammad Suleman ImtiazMadiha MaboosSabahat Jabeen

Published in: International journal of nanomedicine (2021)

The four drugs investigated undergo phase transformation with HNTs. While agitation is an optimum method for loading drugs with various physicochemical attributes into HNTs; solvent system, loading ratios and pH play an important role in the loading efficiency respective to the drug properties. The study supports the capability of developing HNT-based modified release oral dosage forms for drugs with high solubility.

Keyphrases

drug release
drug induced
high throughput
emergency department
human health