Empty spiracles homeobox genes EMX1 and EMX2 regulate WNT pathway activation in sarcomagenesis.

Manuel Pedro Jimenez-GarcíaAntonio Lucena-CacaceDaniel Otero-AlbiolAmancio Carnero

Published in: Journal of experimental & clinical cancer research : CR (2021)

Our data showed that Empty Spiracles Homeobox Genes EMX1 and EMX2 represses WNT signalling and activation of WNT pathway bypass EMX-dependent stemness repression and induces sarcomagenesis. These results also suggest the relevance of the Wnt/b-catenin/stemness axis as a therapeutic target in sarcoma.

Keyphrases

stem cells
cell proliferation
epithelial mesenchymal transition
genome wide
machine learning
electronic health record
bioinformatics analysis
gene expression