MLH1 enhances the sensitivity of human endometrial carcinoma cells to cisplatin by activating the MLH1/c-Abl apoptosis signaling pathway.

Yue LiShihong ZhangYuanjian WangJin PengFang FangXingsheng Yang

Published in: BMC cancer (2018)

MLH1 may render endometrial carcinoma cells more sensitive to cisplatin by activating the MLH1/c-Abl apoptosis signaling pathway. In addition, an applicable adenovirus vector (ADV-MLH1) for MLH1 overexpression in endometrial carcinoma was generated. Thus, ADV-MLH1 might be a novel potential therapeutic target for endometrial carcinoma.

Keyphrases

signaling pathway
endometrial cancer
pi k akt
oxidative stress
cell cycle arrest
endoplasmic reticulum stress
epithelial mesenchymal transition
endothelial cells
cell death
cell proliferation
transcription factor
climate change
gene therapy