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Canary: an automated tool for the conversion of MaCH imputed dosage files to PLINK files.

Adam N BennettJethro RainfordXiaotai HuangQian HeKei-Hang Katie Chan
Published in: BMC bioinformatics (2022)
Until now, conversion of imputed data in the form of MaCH mldose and mlinfo files needed to be completed manually. Canary uses singularity container technology to allow users to automatically convert these MaCH files into PLINK compatible files. Additionally, Canary provides researchers with a platform to conduct GWAS analysis more easily as it contains essential software needed for conducting GWAS studies, such as PLINK and Bioconductor. We hope that this tool will greatly increase the ease at which researchers can perform GWAS with imputed data, particularly on HPC environments.
Keyphrases
  • electronic health record
  • big data
  • data analysis
  • genome wide association study