MiR-30c-5p loss-induced PELI1 accumulation regulates cell proliferation and migration via activating PI3K/AKT pathway in papillary thyroid carcinoma.

Tingting ZhengYouxing ZhouXiaowei XuXin QiJiameng LiuYanan PuShan ZhangXuerong GaoXinkai LuoMei LiXuefeng WangLiyang DongYing WangChaoming Mao

Published in: Journal of translational medicine (2022)

This study not only supported the first evidence that miR-30c-5p loss-induced PELI1 accumulation facilitated cell proliferation and migration by activating the PI3K-AKT pathway in PTC but also provided novel insights into PTC therapy based on miR-carrying-hUCMSC-EVs.

Keyphrases

cell proliferation
long non coding rna
long noncoding rna
high glucose
single cell
cell therapy
diabetic rats
signaling pathway
lymph node
drug induced
squamous cell carcinoma
lymph node metastasis
endothelial cells
mesenchymal stem cells