Determinants of label non-adherence to non-vitamin K oral anticoagulants in patients with newly diagnosed atrial fibrillation.
Jaap SeeligEmmy M Trinks-RoerdinkGordon ChuR PistersL J H J TheunissenSerge A TrinesL PosC J H J KirchhofS F A M S de JongF R den HartogA P van AlemP E PolakR G TielemanP H van der VoortTimo LenderinkA M OttenJonas S S G de JongY L GuJ G L M LuermansM J H A KruipS A J TimmerTim A C de VriesHugo Ten CateG J GeersingF H RuttenM V HuismanM E W HemelsPublished in: European heart journal open (2022)
In newly diagnosed Dutch AF patients, off-label dosing of NOACs was seen in only 6.6% of patients, most often underdosing. In this study, determinants of off-label dosing were age, renal function, weight, anaemia, active malignancy, and concomitant use of antiplatelets.