Biomarker Periodic Repolarization Dynamics Indicates Enhanced Risk for Arrhythmias and Sudden Cardiac Death in Myocardial Infarction in Pigs.

Julia BauerJulia VlcekValerie PaulyNora HesseRuibing XiaLi Mo Aparna Sharma Chivukula Hannes VillgraterMarie DresslerBianca HildebrandEckhard Wolf Konstantinos D Rizas Axel Bauer Stefan Kääb Philipp Tomsits Dominik Schüttler Sebastian Clauss

Published in: Journal of the American Heart Association (2024)

We demonstrate that ischemic heart failure leads to significant proarrhythmogenic autonomic remodeling. The concomitant elevation of PRD levels in pigs with ischemic heart failure and pigs with MI-related ventricular fibrillation/SCD suggests PRD as a biomarker for autonomic remodeling and as a potential predictive biomarker for ventricular arrhythmias/survival in the context of MI.

Keyphrases

heart failure
left ventricular
heart rate variability
heart rate
cardiac resynchronization therapy
acute heart failure
atrial fibrillation
ischemia reperfusion injury
congenital heart disease
cerebral ischemia
blood pressure
oxidative stress
blood brain barrier
brain injury
free survival
climate change