Genome-wide association study of coronary artery calcified atherosclerotic plaque in African Americans with type 2 diabetes.

Jasmin DiversNicholette D PalmerCarl D LangefeldW Mark BrownLingyi LuPamela J HicksS Carrie SmithJianzhao XuJames G TerryThomas C RegisterLynne E WagenknechtJohn S ParksLijun MaGary C ChanSarah G BuxbaumAdolfo CorreaSolomon MusaniJames G WilsonHerman A TaylorDonald W BowdenJohn Jeffrey CarrBarry I Freedman

Published in: BMC genetics (2017)

Genetic association between SNPs on chromosomes 2, 6, 7, 9, 16 and 18 and CAC were detected in AAs with T2D from AA-DHS and replicated in the JHS. These data support a role for genetic variation on these chromosomes as contributors to CAC in AAs with T2D, as well as to variation in CAC between populations of African and European ancestry.

Keyphrases

genome wide association study
coronary artery
genome wide
pulmonary artery
coronary artery disease
electronic health record
big data
copy number
dna methylation
gene expression
machine learning