Selective lysine-specific demethylase 1 inhibitor, NCL1, could cause testicular toxicity via the regulation of apoptosis.

Satoshi NozakiTaku Naiki Aya Naiki-ItoShoichiro IwatsukiTomoki TakedaToshiki EtaniTakashi NagaiKeitaro IidaHiroyuki KatoTakayoshi SuzukiSatoru TakahashiYukihiro UmemotoTakahiro Yasui

Published in: Andrology (2020)

High-dose NCL1 treatment targeting LSD1 caused dysfunctional spermatogenesis and induced caspase-dependent apoptosis. This suggests the LSD1 inhibitor may cause testicular toxicity via the regulation of apoptosis.

Keyphrases

oxidative stress
cell death
endoplasmic reticulum stress
cell cycle arrest
high dose
diabetic rats
induced apoptosis
low dose
signaling pathway
amino acid