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Effect of a gonadotropin-releasing hormone analog for ovarian function preservation after intravenous cyclophosphamide therapy in systemic lupus erythematosus patients: a retrospective inception cohort study.

Tomohiro KogaMasataka UmedaYushiro EndoMidori IshidaYuya FujitaSosuke TsujiAyuko TakataniToshimasa ShimizuRemi SumiyoshiTakashi IgawaShoichi FukuiAyako NishinoShin-Ya KawashiriNaoki IwamotoKunihiro IchinoseMami TamaiHideki NakamuraTomoki OriguchiNaoko MurakamiMichio KitajimaAtsushi Kawakami
Published in: International journal of rheumatic diseases (2018)
The combined use of GnRH-a with IVCY therapy was associated with a significant reduction of POF among premenopausal women with SLE, suggesting that the addition of GnRH-a can be a strategy to prevent POF among premenopausal women with SLE after IVCY therapy.
Keyphrases
  • systemic lupus erythematosus
  • high dose
  • ejection fraction
  • newly diagnosed
  • low dose
  • disease activity
  • prognostic factors
  • bone marrow
  • cell therapy
  • patient reported
  • smoking cessation