Effect of Race on Prediction of Brain Amyloidosis by Plasma Aβ42/Aβ40, Phosphorylated Tau, and Neurofilament Light.
Nicholas N AshtonJonathan M SchottNicholas James AshtonRachel L HensonKevin E YarasheskiTim WestMathew R MeyerKristopher M KirmessYan LiBenjamin SaefKrista L MoulderDavid BradfordAnne M FaganBrian A GordonTammie L S BenzingerJoyce Joy E Balls-BerryRandell J BatemanChengjie XiongHenrik ZetterbergKaj BlennowJohn C MorrisPublished in: Neurology (2022)
Models predicting brain amyloidosis using a high-performance plasma Aβ42/Aβ40 assay may provide an accurate and consistent measure of brain amyloidosis across AA and NHW groups, but models based on plasma p-tau181, p-tau231, and NfL may perform inconsistently and could result in disproportionate misdiagnosis of AA individuals.