Efficacy of non-steroidal anti-inflammatory drugs on zoledronic acid-induced acute-phase reactions: randomized, open-label, Japanese OZ study.

Nobukazu OkimotoAkinori SakaiToru YoshiokaTomohiro KobayashiKei AsanoShojiro AkahoshiToru IshikuraShito FukuharaYoshifumi FuseToshiyuki MizunoYuji KataeHidehiro MatsumotoTakayuki OgawaShigeki NishidaSatoshi IkedaKunitaka MenukiJun SaitoYuichi OkazakiNaoyuki MizunoSaeko Fujiwara

Published in: Journal of bone and mineral metabolism (2019)

Zoledronic acid-induced APRs appeared to be suppressed by loxoprofen. Known risk/protective factors, including prior osteoporosis treatment, were applicable to Japanese patients.

Keyphrases

anti inflammatory drugs
open label
phase iii
phase ii
clinical trial
double blind
phase ii study
postmenopausal women
bone mineral density
study protocol
radiation therapy