Exploratory analysis of the effect of helminth infection on the immunogenicity and efficacy of the asexual blood-stage malaria vaccine candidate GMZ2.
Odilon NouatinJuliana Boex MengueJean Claude Dejon AgobéRolf FendelJavier IbáñezUlysse Ateba NgoaJean Ronald EdoaRoméo Bayodé AdegbiteYabo Josiane HonkpehedjiJeannot Fréjus ZinsouAurore Bouyoukou HounkpatinKabirou MoutairouAndreas HomoetMeral EsenAndrea KreidenweissStephen L HoffmanMichael TheisenAdrian John Frederick LutyBertrand LellSelidji Todagbe AgnandjiGhyslain Mombo-NgomaMichael RamharterPeter KremsnerBenjamin MordmüllerAdegnika Ayola AkimPublished in: PLoS neglected tropical diseases (2021)
Our results suggest that helminth infection may reduce naturally acquired and vaccine-induced protection against malaria. Vaccine-specific antibody concentrations on D84 may be associated with protection in participants with no helminth infection. These results suggest that helminth infection affect malaria vaccine immunogenicity and efficacy in helminth endemic countries.