A circulating cell population showing both M1 and M2 monocyte/macrophage surface markers characterizes systemic sclerosis patients with lung involvement.
Amelia Chiara TrombettaStefano SoldanoPaola ContiniVeronica TomatisBarbara RuaroSabrina PaolinoRenata BrizzolaraPaola MontagnaAlberto SulliCarmen PizzorniVanessa SmithMaurizio CutoloPublished in: Respiratory research (2018)
The present study shows for the first time, through a wide flow cytometry surface marker analysis, that higher circulating mixed M1/M2 monocyte/macrophage cell percentages are associated with ILD, sPAP and anti-topoisomerase antibody positivity in SSc, opening the path for research on their possible role as pathogenic or biomarker elements for SSc lung involvement.