Single-Cell RNA Sequencing Identifies Candidate Renal Resident Macrophage Gene Expression Signatures across Species.
Kurt A ZimmermanMelissa R BentleyJeremie M P LeverZhang LiDavid K CrossmanCheng Jack SongShanrun LiuMichael R CrowleyJames F GeorgeMichal MrugBradley K YoderPublished in: Journal of the American Society of Nephrology : JASN (2019)
Based on transcriptional signatures, our data indicate that there is a conserved population of innate immune cells across multiple species that have been defined as resident macrophages in the mouse. Further, we identified potential cell surface markers to allow for future identification and characterization of this candidate resident macrophage population in mouse, rat, and pig translational studies.
Keyphrases
- single cell
- gene expression
- cell surface
- innate immune
- patient safety
- genome wide
- quality improvement
- induced apoptosis
- rna seq
- dna methylation
- adipose tissue
- transcription factor
- emergency medicine
- oxidative stress
- cell cycle arrest
- current status
- endoplasmic reticulum stress
- human health
- risk assessment
- case control
- data analysis