Immune phenotype changes in IgG4-related disease: CD161 + Treg and Foxp3 + Treg.
Wenjie BianYingni LiFeng SunXiaolin SunRu LiChangsheng XiaJiangnan FuYuxin ZhangShuang ChenYan-Ying LiuPublished in: Clinical rheumatology (2022)
Immune phenotypes were altered in IgG4-RD. Treg/Teff balance was shifted toward Treg in IgG4-RD. CD161 + Treg was likely to be involved in the pathogenesis of IgG4-RD. Key Points •Immune phenotypes were altered in B cells, T cells, and NK cells in IgG4-RD. •Treg/Teff balance was shifted toward Treg in IgG4-RD. •CD161+ Treg maybe play a proinflammatory role in IgG4-RD.
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