Human-Derived Induced GABAergic Progenitor Cells Improve Cognitive Function in Mice and Inhibit Astrocyte Activation with Anti-Inflammatory Exosomes.

Chunxia ChenZhaohui LanXihe TangWan ChenXing ZhouHua SuRixiang SuZhaolin ChenHongbo ChenYing GuoWenbing Deng

Published in: Annals of neurology (2024)

Taken together, these findings support the hypothesis that hiMGEs transplantation is an alternative treatment for neuronal loss in AD and demonstrate that exosomes with anti-inflammatory activity derived from hiMGEs are important factors for graft survival. ANN NEUROL 2024.

Keyphrases

mesenchymal stem cells
anti inflammatory
endothelial cells
stem cells
high glucose
induced pluripotent stem cells
high fat diet induced
type diabetes
cell therapy
metabolic syndrome
skeletal muscle
drug induced
free survival
neural network
brain injury