Peribiliary Gland Niche Participates in Biliary Tree Regeneration in Mouse and in Human Primary Sclerosing Cholangitis.

Carpino Guido Lorenzo Nevi Diletta OveriVincenzo CardinaleWei-Yu LuSabina Di MatteoSamira SafarikiaPasquale Bartolomeo BerlocoRosanna VenerePaolo OnoriAntonio FranchittoStuart J ForbesDomenico AlvaroEugenio Gaudio

Published in: Hepatology (Baltimore, Md.) (2019)

We demonstrated the involvement of PBG cells in regenerating the injured biliary epithelium and identified the signaling pathways driving BTSC activation. These results could have relevant implications on the pathophysiology and treatment of cholangiopathies.

Keyphrases

induced apoptosis
signaling pathway
endothelial cells
stem cells
cell cycle arrest
oxidative stress
cell death
cell proliferation
replacement therapy