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Investigation of anti-Toxocara and anti-toxoplasma antibodies in patients with schizophrenia disorder.

Shahram KhademvatanNiloufar KhajeddinSakineh IzadiElham Yousefi
Published in: Schizophrenia research and treatment (2014)
Objective. The aim of the present study was to examine the relationship between Toxoplasma gondii and Toxocara spp. infections in patients with schizophrenia disorder. Method. A total of 100 patients with schizophrenia disorder and 95 healthy individuals participated in the study. Participants were tested for the presence of anti-T. gondii and anti-Toxocara spp. antibodies by ELISA and Western blotting. Data were analyzed using Chi-square test and Fisher 9 s exact test. Results. There were no differences in T. gondii IgG seroprevalence between patients with schizophrenia and healthy individuals (P = 0.1), but there were differences in seroprevalence between males and females with schizophrenia (P = 0.009). In contrast, Toxocara spp. IgG seroprevalence was greater in patients with schizophrenia disorder than in healthy individuals (P = 0.02), but there were no differences in seroprevalence between men and women with schizophrenia (P = 0.5). Finally, there were no differences in seroprevalence of T. gondii or Toxocara spp. IgG among different subtypes of schizophrenia, various age groups, residential area, or clinical course of treatment (P > 0.05). Conclusion. The present study suggests that patients with schizophrenia disorder are at elevated risk of Toxocara spp. infection. Moreover, contamination with T. gondii is a risk factor for schizophrenia in women.
Keyphrases
  • bipolar disorder
  • toxoplasma gondii
  • magnetic resonance
  • metabolic syndrome
  • computed tomography
  • climate change
  • south africa
  • adipose tissue
  • polycystic ovary syndrome
  • heavy metals
  • big data