Genetic mutation in Escherichia coli genome during adaptation to the murine intestine is optimized for the host diet.
Tomoya TsukimiNozomu ObanaSuguru ShigemoriKazuharu ArakawaEiji MiyauchiJiayue YangIsaiah SongYujin AshinoMasataka WakayamaTomoyoshi SogaMasaru TomitaHiroshi OhnoHirotada MoriShinji FukudaPublished in: mSystems (2024)
K-12 strain are selected in response to the intestinal environment and facilitate efficient utilization of abundant nutrients in the germ-free mouse intestine. Our study provides a better understanding of these intestinal adaptation mechanisms of gut microbes.