Dickkopf-1 (DKK1) blockade mitigates osteogenesis imperfecta (OI) related bone disease.
Jih-Yang KoFeng-Sheng WangWei-Shiung LianFu-Shine YangJeng-Wei ChenPo-Hua HuangChin-Yi LiaoShu-Jui KuoPublished in: Molecular medicine (Cambridge, Mass.) (2024)
Our study elucidates that DKK1-AS has the capability to enhance bone mechanical properties, restore the transcription of osteogenic genes, promote osteogenesis, and inhibit osteoclastogenesis in OI mice.
Keyphrases
- bone regeneration
- bone loss
- bone mineral density
- mesenchymal stem cells
- soft tissue
- bone marrow
- genome wide
- transcription factor
- high fat diet induced
- postmenopausal women
- radiation therapy
- radiation induced
- dna methylation
- lps induced
- gene expression
- metabolic syndrome
- inflammatory response
- insulin resistance
- wild type