A Population of Tumor-Infiltrating CD4+ T-cells Co-expressing CD38 and CD39 is Associated with Checkpoint Inhibitor Resistance.
Ankita MitraBrian ThompsonAnn StrangeCarol M AmatoMelinda VassalloIgor DolgalevJonathan Hester-McCulloughTomoaki MuramatsuDiana KimonoAmrutesh S PuranikJeffrey S WeberDavid M WoodsPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
These results demonstrate that a novel population of CD4+ T-cells co-expressing CD38 and CD39 is found both in the peripheral blood and tumor of melanoma patients and is associated with checkpoint immunotherapy resistance.