Quantitative cellular pathology of the amygdala in temporal lobe epilepsy and correlation with magnetic resonance imaging volumetry, tissue microstructure, and sudden unexpected death in epilepsy risk factors.
Hou Wang LamSmriti PatodiaClaudia ZeicuYau Mun LimAlicja MrzyglodCatherine ScottJoana OliveiraJane De TisiAntoine LegouhyHui ZhangMatthias J KoeppBeate DiehlMaria ThomPublished in: Epilepsia (2024)
Histological quantitation of amygdala microstructure can shed light on enlargement and diffusion imaging alterations in epilepsy to explore possible mechanisms of amygdala dysfunction, including mTOR pathway activation, that in turn may increase the risk for SUDEP.
Keyphrases
- temporal lobe epilepsy
- magnetic resonance imaging
- white matter
- risk factors
- high resolution
- ms ms
- mass spectrometry
- computed tomography
- oxidative stress
- cell proliferation
- functional connectivity
- multiple sclerosis
- sensitive detection
- contrast enhanced
- living cells
- fluorescent probe
- magnetic resonance
- tandem mass spectrometry
- photodynamic therapy
- resting state
- high performance liquid chromatography
- quantum dots
- prefrontal cortex
- single molecule