Aging Alters the Aortic Proteome in Health and Thoracic Aortic Aneurysm.
Daniel J TyrrellJudy ChenBenjamin Y LiSherri C WoodWendy Rosebury-SmithHenriette A RemmerLongtan JiangMin ZhangMorgan SalmonGorav AilawadiBo YangDaniel R GoldsteinPublished in: Arteriosclerosis, thrombosis, and vascular biology (2022)
Aging transforms the human aortic proteome from health to TAA, leading to a differential regulation of biological processes. Our results suggest that the development of therapies to mitigate vascular diseases including TAA may need to be modified depending on subject age.