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Treatment patterns and related clinical consequences in adults with asthma.

Piyameth DilokthornsakulAngela M ThompsonJonathan D Campbell
Published in: The Journal of asthma : official journal of the Association for the Care of Asthma (2018)
A total of 6,354 mild-asthma patients and 5,695 severe-asthma patients were included. In mild-asthma, when compared with No Change in Treatment Step, Step-down was associated with a lower risk of future clinical events [adjusted odds ratio (OR) 0.80, 95% confidence interval (95% CI); 0.69-0.94], while Step-up was not associated with a change in clinical events [OR 0.98, 95% CI: 0.77-1.27]. In severe-asthma patients, Step-down was not associated with a change in clinical events [OR 0.94, 95% CI: 0.81-1.10], while Step-up was associated with a higher risk of future clinical events [OR 2.07, 95% CI: 1.29-3.33]. Our findings reassure the appropriateness of stepping-down treatment in mild-asthma patients. Clinicians should closely monitor and/or provide detailed asthma action plans for severe-asthma patients who are stepping-up treatment.
Keyphrases
  • end stage renal disease
  • ejection fraction
  • newly diagnosed
  • chronic obstructive pulmonary disease
  • prognostic factors
  • lung function
  • patient reported outcomes
  • air pollution