Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models of Primary and Recurrent Meningioma.
Huiyuan ZhangLin QiYuchen DuL Frank HuangFrank K BraunMari KogisoYanling ZhaoCan LiHolly B LindsaySibo ZhaoSarah G InjacPatricia A BaxterJack Meng-Fen SuClifford StephanCharles KellerKent A HeckAkdes HarmanciArif O HarmanciJianhua YangTiemo J KlischXiao-Nan LiAkash J PatelPublished in: Cancers (2020)
Meningiomas are not very amenable to PDOX modeling, for reasons that remain unclear. Yet at least some of the most malignant tumors can be modeled, and cryopreserved primary tumor cells can create large panels of tumors that can be used for preclinical drug testing.