Stat3 role in the protective effect of FXR Agonist in parenteral nutrition-associated cholestasis.

Swati Ghosh Michael W Devereaux Aimee L Anderson Karim Christian El Kasmi Ronald J Sokol

Published in: Hepatology communications (2023)

STAT3 signaling mediated in part the protective effects of GW4064 in the PNAC mouse, and in HepG2 cells and hepatocytes exposed to either IL-1β or phytosterols, 2 factors critical in PNAC pathogenesis. These data demonstrate that FXR agonists may mediate hepatoprotective effects in cholestasis by inducing STAT3 signaling.

Keyphrases

cell proliferation
drug induced
liver injury
electronic health record
machine learning
artificial intelligence
deep learning
data analysis