Methoxy-Substituted γ-Oxa-ε-Lactones Derived from Flavanones-Comparison of Their Anti-Tumor Activity In Vitro.

Aleksandra Pawlak Marta Henklewska Beatriz Hernández SuárezMonika SiepkaWitold GładkowskiCzesław WawrzeńczykKarolina Motykiewicz-PersBożena Obmińska-Mrukowicz

Published in: Molecules (Basel, Switzerland) (2021)

Methoxy-substituted flavanone-derived lactones effectively kill canine lymphoma/leukemia cells in vitro and, thanks to their synergistic action with glucocorticoids, may potentially be applied in the treatment of hematopoietic cancers.

Keyphrases

molecular docking
bone marrow
induced apoptosis
cell cycle arrest
acinetobacter baumannii
klebsiella pneumoniae
cancer therapy
cystic fibrosis
combination therapy
cell death
young adults
drug resistant
clinical evaluation