TGF-β orchestrates the phenotype and function of monocytic myeloid-derived suppressor cells in colorectal cancer.

Luciana GneoNagy RizkallaRahul HejmadiFrancis MussaiCarmela de SantoGary M Middleton

Published in: Cancer immunology, immunotherapy : CII (2021)

Our study demonstrates the cross-talk between CRC cells, M-MDSCs and T cells. Characterisation of CRC M-MDSCs point to therapeutic avenues to target these cells in addition to TGF-β blockade.

Keyphrases

induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
cell proliferation