TGF-β orchestrates the phenotype and function of monocytic myeloid-derived suppressor cells in colorectal cancer.
Luciana GneoNagy RizkallaRahul HejmadiFrancis MussaiCarmela de SantoGary M MiddletonPublished in: Cancer immunology, immunotherapy : CII (2021)
Our study demonstrates the cross-talk between CRC cells, M-MDSCs and T cells. Characterisation of CRC M-MDSCs point to therapeutic avenues to target these cells in addition to TGF-β blockade.