Integrated Bioinformatics Analysis and Verification of Gene Targets for Myocardial Ischemia-Reperfusion Injury.

Jianru WangXiaohui LiGuangcao PengGenhao FanMengmeng ZhangJian Chen

Published in: Evidence-based complementary and alternative medicine : eCAM (2022)

Emr1, Tyrobp, Itgb2, Fcgr2b, Cybb, and Fcer1g might be critical in the pathological process of MIRI, and the natural products (araloside C, glycyrrhizic acid, ophiopogonin D, polyphyllin I, and punicalagin) targeting these hub genes exhibited potential therapeutic efficacy on MIRI. Our findings provided new insights to explore the mechanism and treatments for MIRI and revealed new therapeutic targets for natural products with protective properties against MIRI.

Keyphrases

bioinformatics analysis
ischemia reperfusion injury
oxidative stress
genome wide identification
left ventricular
copy number
cancer therapy
heart failure
transcription factor
climate change
drug delivery