The combined use of steroids and immune checkpoint inhibitors in brain metastasis patients: a systematic review and meta-analysis.

Charissa A C JessurunAlexander F C HulsbergenAnouk E de WitIshaan A TewarieTom Jan SnijdersJoost J C VerhoeffJohn G PhillipsDavid A ReardonRania A MekaryMarike L D Broekman

Published in: Neuro-oncology (2021)

Administration of steroids was associated with significantly worse OS and PFS in BM patients receiving ICI. Further research on dose, timing, and duration of steroids is needed to elucidate the cause of this association and optimize outcomes in BM patients receiving ICI.

Keyphrases

end stage renal disease
ejection fraction
prognostic factors
peritoneal dialysis
white matter
resting state
metabolic syndrome
patient reported outcomes
functional connectivity
adipose tissue
brain injury