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Design, Synthesis, and Spectroscopic Studies of Some New α-Aminophosphonate Analogues Derived from 4-Hydroxybenzaldehyde with Special Reference to Anticancer Activity.

Omar M AliMohammed T AlotaibiYasser H ZakiHamada H Amer
Published in: Drug design, development and therapy (2022)
α-aminophosphonate derivatives, arylidines, and disphosphonate derivatives derived from 4-hydroxybenzaldehyde were synthesized, purified, elucidated by spectroscopic analysis, and finally tested against carcinoma breast cancer to give high to moderate to low activity.
Keyphrases
  • molecular docking
  • structure activity relationship
  • molecular dynamics simulations
  • high intensity
  • data analysis