Integrated analysis of ultra-deep proteomes in cortex, cerebrospinal fluid and serum reveals a mitochondrial signature in Alzheimer's disease.

Hong WangKaushik Kumar DeyPing-Chung ChenYuxin LiMingming NiuJi-Hoon ChoXusheng WangBing BaiYun JiaoSurendhar Reddy ChepyalaVahram HaroutunianBin ZhangThomas G BeachJunmin Peng

Published in: Molecular neurodegeneration (2020)

Our results demonstrate that novel AD biomarker candidates are identified and confirmed by proteomic studies of brain tissue and biofluids, providing a rich resource for large-scale biomarker validation for the AD community.

Keyphrases

cerebrospinal fluid
healthcare
oxidative stress
mental health
white matter
cognitive decline
high resolution
case control
multiple sclerosis
mass spectrometry
mild cognitive impairment