A genome-wide association study of contralateral breast cancer in the Women's Environmental Cancer and Radiation Epidemiology Study.

Xiaohui SunAnne S ReinerAnh Phong TranGordon P WattJung Hun OhLene MellemkjærCharles F LynchJulia A KnightEsther M JohnKathleen E MaloneXiaolin LiangMeghan WoodsAndriy DerkachPatrick ConcannonJonine L BernsteinXiang Shu

Published in: Breast cancer research : BCR (2024)

The present GWAS identified two previously unreported loci with suggestive genome-wide significance. We also confirm that an elevated risk of CBC is associated with a comprehensive breast cancer susceptibility PRS that is independent of known breast cancer risk factors. These findings advance our understanding of genetic risk factors involved in CBC etiology.

Keyphrases

risk factors
genome wide association study
genome wide
dna methylation
breast cancer risk
polycystic ovary syndrome
gene expression
radiation therapy
insulin resistance
young adults
skeletal muscle
radiation induced
pregnancy outcomes
metabolic syndrome
cervical cancer screening