Phenobarbital pharmacokinetics in neonates and infants during extracorporeal membrane oxygenation.

Pavla Pokorná Martin SimaVáclav VobrubaDick TibboelOndřej Slanař

Published in: Perfusion (2018)

Body weight was shown to be the main PK covariate of phenobarbital disposition. Subsequent dosing nomograms are provided for phenobarbital dosing during ECMO.

Keyphrases

extracorporeal membrane oxygenation
body weight
acute respiratory distress syndrome
respiratory failure
mechanical ventilation
intensive care unit