Inflammatory cytokine oncostatin M induces endothelial activation in macro- and microvascular endothelial cells and in APOE*3Leiden.CETP mice.
Danielle van KeulenMarianne G PouwerGerard PasterkampAlain J van GoolMaarten D Sollewijn GelpkeHans M G PrincenDennie TempelPublished in: PloS one (2018)
OSM induces endothelial activation in vitro in endothelial cells from different vascular beds through activation of the JAK/STAT cascade and in vivo in APOE*3Leiden.CETP mice. Since endothelial activation is an initial step in atherosclerosis development, OSM may play a role in the initiation of atherosclerotic lesion formation.