Brain Structure and Degeneration Staging in Friedreich Ataxia: Magnetic Resonance Imaging Volumetrics from the ENIGMA-Ataxia Working Group.
Ian H HardingSidhant ChopraFilippo ArrigoniSylvia BoeschArturo BrunettiSirio CocozzaLouise A CorbenAndreas DeistungMartin DelatyckiStefano DiciottiImis DoganStefania EvangelistiMarcondes Cavalcante de França JuniorSophia L GörickeNellie Georgiou-KaristianisLaura Ludovica GramegnaPierre-Gilles HenryCarlos R Hernandez-CastilloDiane HutterNeda JahanshadJames M JoersChristophe LengletRaffaele LodiDavid N MannersAlberto R M MartinezAndrea MartinuzziChiara MarziMario MascalchiWolfgang NachbauerChiara PaneDenis PeruzzoPramod Kumar PisharadyGiuseppe PontilloKathrin ReetzThiago Junqueira Ribeiro de RezendeSandro RomanzettiFrancesco SaccàChristoph ScherflerJörg Bernhard SchulzAmbra StefaniClaudia TestaSophia I ThomopoulosDagmar TimmannStefania TirelliCaterina TononMarinela VavlaGary F EganPaul M ThompsonPublished in: Annals of neurology (2021)
FRDA is defined by an evolving spatial profile of neuroanatomical changes beyond primary pathology in the cerebellum and spinal cord, in line with its progressive clinical course. The design, interpretation, and generalization of research studies and clinical trials must consider neuroanatomical staging and associated interindividual variability in brain measures. ANN NEUROL 2021;90:570-583.