Based on Network Pharmacology Tools to Investigate the Molecular Mechanism of Cordyceps sinensis on the Treatment of Diabetic Nephropathy.
Yan LiLei WangBojun XuLiangbin ZhaoLi LiKeyang XuAnqi TangShasha ZhouLu SongXiao ZhangHuakui ZhanPublished in: Journal of diabetes research (2021)
Our study showed that Cordyceps is characterized as multicomponent, multitarget, and multichannel. Cordyceps may play a crucial role in the treatment of DN by targeting TNF, MAPK1, EGFR, ACE, and CASP3 signaling and involved in the inflammatory response, apoptosis, oxidative stress, and insulin resistance.
Keyphrases
- oxidative stress
- inflammatory response
- diabetic nephropathy
- insulin resistance
- small cell lung cancer
- adipose tissue
- rheumatoid arthritis
- signaling pathway
- cell death
- epidermal growth factor receptor
- dna damage
- endoplasmic reticulum stress
- tyrosine kinase
- angiotensin ii
- lipopolysaccharide induced
- diabetic rats
- network analysis
- replacement therapy