Crosstalk between phytochemicals and inflammatory signaling pathways.
Sonima PrasadVishal KumarCharan SinghArti SinghPublished in: Inflammopharmacology (2023)
Novel bioactive constituents from natural sources are actively being investigated. The phytochemicals in these phenolic compounds are believed to have a variety of beneficial effects on human health. Several phenolic compounds have been found in plants. The antioxidant potential of phenols has been discussed in numerous studies along with their anti-inflammatory effects on pro-inflammatory cytokine, inducible cyclooxygenase-2, and nitric oxide synthase. Through current study, an attempt is made to outline and highlight a wide variety of inflammation-associated signaling pathways that have been modified by several natural compounds. These signaling pathways include nuclear factor-kappa B (NF-кB), activator protein (AP)-1, protein tyrosine kinases (PTKs), mitogen-activated protein kinases (MAPKs), nuclear factor erythroid 2-related factor 2 (Nrf2) transcription factors, tyrosine phosphatidylinositol 3-kinase (PI3K)/AKT, and the ubiquitin-proteasome system. In light of the influence of natural substances on signaling pathways, their impact on the production of inflammatory mediator is highlighted in this review.
Keyphrases
- nuclear factor
- signaling pathway
- pi k akt
- oxidative stress
- human health
- toll like receptor
- nitric oxide synthase
- anti inflammatory
- cell cycle arrest
- risk assessment
- transcription factor
- induced apoptosis
- cell proliferation
- nitric oxide
- epithelial mesenchymal transition
- drinking water
- climate change
- amino acid
- protein protein
- inflammatory response
- high resolution
- drug induced
- tyrosine kinase
- cell death
- dna binding
- mass spectrometry
- endoplasmic reticulum stress