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Combining germline, tissue and liquid biopsy analysis by comprehensive genomic profiling to improve the yield of actionable variants in a real-world cancer cohort.

Irene VanniL PastorinoV AndreottiD ComandiniG FornariniM GrassiA PucciniE T TandaA PastorinoV MartelliL MastracciF GrilloF CabidduA GuadagnoS CocoE AllavenaF BarberoW BrunoB DalmassoS E BellomoC MarchiòF SpagnoloS ScialleroE BerrinoPaola Ghiorzo
Published in: Journal of translational medicine (2024)
Our study confirms the clinical relevance of performing extended parallel tumor DNA and cfDNA testing to broaden therapeutic options, to longitudinally monitor cfDNA during patient treatment, and to uncover possible hereditary predisposition following tumor sequencing in patient care.
Keyphrases
  • copy number
  • single cell
  • papillary thyroid
  • case report
  • circulating tumor
  • cell free
  • single molecule
  • squamous cell
  • ionic liquid
  • dna methylation
  • combination therapy
  • young adults
  • childhood cancer
  • genome wide analysis