Supramolecular hydrogels encapsulating bioengineered mesenchymal stem cells for ischemic therapy.
Byung Woo HwangYoung-Eun KimMungu KimSeulgi HanSeoyeon BokKyeng Min ParkAnnadka ShrinidhiKi Su KimG-One AhnSei Kwang HahnPublished in: RSC advances (2018)
We developed supramolecular hyaluronate (HA) hydrogels to encapsulate genetically engineered mesenchymal stem cells (MSCs) for the treatment of limb ischemia. In vivo angiogenic factors could be produced stably by the bioengineered MSCs (BMSCs) within the supramolecular hydrogels showing effective vascular repair and enhanced blood perfusion.
Keyphrases
- mesenchymal stem cells
- umbilical cord
- drug delivery
- hyaluronic acid
- drug release
- extracellular matrix
- tissue engineering
- bone marrow
- water soluble
- energy transfer
- cell therapy
- wound healing
- ischemia reperfusion injury
- brain injury
- computed tomography
- combination therapy
- cerebral ischemia
- quantum dots
- subarachnoid hemorrhage