The capacity of oocytes for DNA repair.
Jessica M StringerAmy WinshipSeng H LiewKarla J HuttPublished in: Cellular and molecular life sciences : CMLS (2018)
Female fertility and offspring health are critically dependent on the maintenance of an adequate supply of high-quality oocytes. Like somatic cells, oocytes are subject to a variety of different types of DNA damage arising from endogenous cellular processes and exposure to exogenous genotoxic stressors. While the repair of intentionally induced DNA double strand breaks in gametes during meiotic recombination is well characterised, less is known about the ability of oocytes to repair pathological DNA damage and the relative contribution of DNA repair to oocyte quality is not well defined. This review will discuss emerging data suggesting that oocytes are in fact capable of efficient DNA repair and that DNA repair may be an important mechanism for ensuring female fertility, as well as the transmission of high-quality genetic material to subsequent generations.
Keyphrases
- dna repair
- dna damage
- dna damage response
- oxidative stress
- induced apoptosis
- healthcare
- public health
- type diabetes
- electronic health record
- diabetic rats
- skeletal muscle
- health information
- gene expression
- circulating tumor
- artificial intelligence
- deep learning
- drug induced
- quality improvement
- health promotion
- endothelial cells
- nucleic acid
- human health