BRD3308 suppresses macrophage oxidative stress and pyroptosis via upregulating acetylation of H3K27 in sepsis-induced acute lung injury.
Bohao LiuNing LiYi LiuYan ZhangLimei QuHongfei CaiYang LiXiaojing WuQing GengPublished in: Burns & trauma (2024)
BRD3308 inhibits oxidative stress and pyroptosis in macrophages by modulating histone acetylation, thereby preventing sepsis-induced ALI. The present study provides a potential strategy and theoretical basis for the clinical treatment of sepsis-induced ALI.