Performance of a multigene genomic classifier and clinical parameters in predicting malignancy in a Southeast Asian cohort of patients with cytologically indeterminate thyroid nodules.
Samantha Peiling YangMin En NgaManish Mahadeorao BundeleSimion I ChioseaSze Hwa TanJeffrey H Y LumRajeev ParameswaranMing Yann LimHao LiWei Keat CheahKathleen Su-Yen SekAndre Teck Huat TanThomas Kwok Seng LohKee Yuan NgiamWee Boon TanXinyong HuangThomas Wai Thong HoKeng Hua LimChwee Ming LimReyaz M SingaporewallaAnil Dinkar RaoNandini C L RaoDennis Yu Kim ChuaDavid Chao-Wu ChinAbigail I WaldVirginia A LiVolsiYuri E NikiforovE Shyong TaiPublished in: Cancer cytopathology (2024)
Even in the current Southeast Asian cohort with nodules that had a high pretest cancer probability, MT could lead to potential avoidance of diagnostic surgery in 42% of patients with Bethesda category III-IV nodules. MT positivity was a stronger predictor of malignancy than clinical parameters.