Early detection of anti-drug antibodies during initiation of anti-tumour necrosis factor therapy predicts treatment discontinuation in inflammatory bowel disease.

Quentin TournierStephane PaulNicolas WillietAnne-Emmanuelle BergerPauline VeyrardGilles BoschettiBertrand Le RoyMartin KillianJean Marc PhelipBernard FlourieStephane NanceyXavier Roblin

Published in: Alimentary pharmacology & therapeutics (2021)

The prevalence of antibodies to anti-TNF is high when detected early using a drug-tolerant assay, and their appearance predicts further treatment discontinuation.

Keyphrases

rheumatoid arthritis
emergency department
risk factors
stem cells
combination therapy
replacement therapy
electronic health record