Heterogeneous Treatment Effects of Intensive Glycemic Control on Kidney Microvascular Outcomes and Mortality in ACCORD.
Vivek CharuJane W LiangGlenn M ChertowJune LiMaria E Montez-RathPascal GeldsetzerIan H de BoerLu TianManjula Kurella TamuraPublished in: Journal of the American Society of Nephrology : JASN (2023)
We found evidence of heterogenous treatment effects of intensive glycemic control on kidney microvascular outcomes in ACCORD as a function of predicted baseline risk of kidney failure. Patients with higher kidney failure risk experienced the most pronounced reduction in kidney microvascular outcomes but also experienced the highest risk of all-cause mortality.